Atypical Antipsychotic Medicines

Analytical challenges

Atypical antipsychotic drugs (AAs) require carefully titrated doses to effectively treat disorders like schizophrenia, making accurate potency measurements especially critical.

But AA development and manufacturing can be challenging. AAs can:

  • be sensitive to oxidation
  • exhibit polymorphism
  • have low solubility in water
  • degrade due to temperature, light and moisture
  • be difficult to formulate and characterize due to:

Confidence in your analytical results

On the path toward successful regulatory approval and release of atypical antipsychotic products, validated methods and highly-characterized reference standards are critical for accurate and reliable analytical results.

AA standards and solutions from USP include stability-indicating chromatographic methods and Reference Standards in the Risperidone API USP-NF monograph and validated assay and impurity methods published in Pharmacopeial Forum for testing Lurasidone Hydrochloride, which is only slightly soluble in water, ethanol and acetone.

As global awareness of mental health needs increases, so will the demand for safe, high-quality and effective generic versions of atypical antipsychotics like lurasidone, paliperidone, olanzapine, risperidone, ziprasidone, aripiprazole, quetiapine, and brexpiprazole.

Explore USP’s solutions for atypical antipsychotics:

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Aripiprazole

Aripiprazole

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Pharmaceutical Analytical Impurities

Brexpiprazole

Brexpiprazole

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Pharmaceutical Analytical Impurities

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Lurasidone - NEW UPDATE

Lurasidone - NEW UPDATE

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USP Monograph Olanzapine

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Olanzapine

Olanzapine

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USP Monograph Olanzapine

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Paliperidone

Paliperidone

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Risperidone

Risperidone

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Quetiapine

Quetiapine

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Ziprasidone

Ziprasidone

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